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Cho, Joo-Youn
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Department

Clinical Pharmacology and Therapeutics

Specialty

Pharmacometabolomics , Pharmacogenomics , Clinical drug development

Appointment
Research Profiles

Education / Career

Education / Career
Article The pharmacokinetic, safety, and tolerability profiles of eslicarbazepine acetate are comparable between Korean and White subjects
Announcements Clin Transl Sci Date of publication 202209
Co-researcher Sejung Hwang, Soyoung Lee, Eunwoo Kim, Inyoung Hwang, Joo-Youn Cho, Jae-Yong Chung, In-Jin Jang, Jaeseong Oh
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/35727711/
Education / Career
Article Identification of Serum Metabolites for Predicting Chronic Kidney Disease Progression according to Chronic Kidney Disease Cause
Announcements Metabolites Date of publication 202211
Co-researcher Eunjeong Kang, Yufei Li, Bora Kim, Ki Young Huh, Miyeun Han, Jung-Hyuck Ahn, Hye Youn Sung, Yong Seek Park, Seung Eun Lee, Sangjun Lee, Sue K Park, Joo-Youn Cho, Kook-Hwan Oh
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/36422264/
Education / Career
Article Association of Metabolic Signatures with Nonalcoholic Fatty Liver Disease in Pediatric Population
Announcements Metabolites Date of publication 202209
Co-researcher Woori Chae, Kyung Jae Lee, Ki Young Huh, Jin Soo Moon, Jae Sung Ko, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/36144285/
Education / Career
Article Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D
Announcements Nat Commun Date of publication 202210
Co-researcher Yun Seok Kim, Bongsub Ko, Da Jung Kim, Jihoon Tak, Chang Yeob Han, Joo-Youn Cho, Won Kim, Sang Geon Kim
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/36241614/
Education / Career
Article Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue
Announcements Metabolites Date of publication 202210
Co-researcher Jihyun Kang, Jeong Yeon Kim, Youjin Jung, Seon Uk Kim, Eun Young Lee, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/36295908/
Education / Career
Article Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects
Announcements Transl Clin Pharmacol Date of publication 202203
Co-researcher Yewon Park, WonTae Jung, Eunsol Yang, Kyu-Yeol Nam, Woo-Ri Bong, Jaehee Kim, Kyu Yeon Kim, SeungHwan Lee, Joo-Youn Cho, Jang-Hee Hong, JaeWoo Kim
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/35419311/
Education / Career
Article An Improved Method to Quantify Short-Chain Fatty Acids in Biological Samples Using Gas Chromatography-Mass Spectrometry
Announcements Metabolites Date of publication 202206
Co-researcher Kyeong-Seog Kim, Yujin Lee, Woori Chae, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/35736458/
Education / Career
Article Key Considerations for Phase 2 or 3 Clinical Study Design of Anti-Inflammatory Agent for COVID-19 Treatment
Announcements Frontiers in pharmacology. Date of publication 202206
Co-researcher Yewon Park, Joo Young Na, Joo-Youn Cho, Jaeseong Oh, Su-Jin Rhee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/35721224/
Education / Career
Article Pharmacokinetic and Pharmacodynamic Characteristics of Tripegfilgrastim, a Pegylated G-CSF, in Pediatric Patients with Solid Tumors
Announcements Clin Pharmacol Ther Date of publication 202201
Co-researcher Soyoung Lee, Kyung Taek Hong, Seol Ju Moon, Jung Yoon Choi, Che Ry Hong, Hee Young Shin, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, Jaeseong Oh, Hyoung Jin Kang
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34605552/
Education / Career
Article A validated simple LC-MS/MS method for quantifying trimethylamine N-oxide (TMAO) using a surrogate matrix and its clinical application
Announcements Translational and clinical pharmacology. Date of publication 202112
Co-researcher Yufei Li, Jihyun Kang, Yujin Lee, Jae-Yong Chung, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/35024362/
Education / Career
Article Metabolomic Signatures for the Effects of Weight Loss Interventions on Severe Obesity in Children and Adolescents
Announcements Metabolites Date of publication 202112
Co-researcher Min-Ji Sohn, Woori Chae, Jae-Sung Ko, Joo-Youn Cho, Ji-Eun Kim, Ji-Yeob Choi, Han-Byul Jang, Hye-Ja Lee, Sang-Ick Park, Kyung-Hee Park, Peter J van der Spek, Jin-Soo Moon
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/35050149/
Education / Career
Article Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase
Announcements Clin Transl Sci Date of publication 202112
Co-researcher Jihyun Kang, Andrew HyoungJin Kim, Inseung Jeon, Jaeseong Oh, In-Jin Jang, SeungHwan Lee, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34863048/
Education / Career
Article Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series
Announcements Clin Transl Sci Date of publication 202111
Co-researcher Pyoeng Gyun Choe, Sae Im Jeong, Chang Kyung Kang, Liju Yang, SeungHwan Lee, Joo-Youn Cho, Seung Seok Han, Dong Ki Kim, Sang Min Lee, Wan Beom Park, Myoung-Don Oh, Nam Joong Kim
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34761554/
Education / Career
Article Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects
Announcements Int J Clin Pharmacol Ther Date of publication 202110
Co-researcher Hyewon Chung, Seo Hyun Yoon, Joo-Youn Cho, Hee Kyung Yeo, Dongseong Shin, Ji-Young Park
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34423771/
Education / Career
Article Effects of vancomycin-induced gut microbiome alteration on the pharmacodynamics of metformin in healthy male subjects
Announcements Clin Transl Sci Date of publication 202109
Co-researcher Eunwoo Kim, Andrew HyoungJin Kim, Yujin Lee, Sang Chun Ji, Joo-Youn Cho, Kyung-Sang Yu, Jae-Yong Chung
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33982376/
Education / Career
Article Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform
Announcements Transl Clin Pharmacol Date of publication 202109
Co-researcher Byungwook Kim, Deok Yong Yoon, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu, Joo-Youn Cho, Jaeseong Oh
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34621706/
Education / Career
Article Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem
Announcements Sci Rep Date of publication 202109
Co-researcher Seonghae Yoon, Seongmee Jeong, Eben Jung, Ki Soon Kim, Inseung Jeon, Yujin Lee, Joo-Youn Cho, Woo-Yong Oh, Jae-Yong Chung
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34580385/
Education / Career
Article Changes in the gut microbiome influence the hypoglycemic effect of metformin through the altered metabolism of branched-chain and nonessential amino acids
Announcements Diabetes Res Clin Pract Date of publication 202108
Co-researcher Yujin Lee, Andrew HyoungJin Kim, Eunwoo Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Jae-Yong Chung, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34329692/
Education / Career
Article Urine 5-Eicosatetraenoic Acids as Diagnostic Markers for Obstructive Sleep Apnea
Announcements Antioxidants (Basel) Date of publication 202108
Co-researcher Hyun-Woo Shin, Kumsun Cho, Chae-Seo Rhee, Il-Hee Hong, Seok Hyun Cho, Sung Wan Kim, Jiyoung Kim, Daeho So, Joo-Youn Cho, Jong-Wan Park
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34439490/
Education / Career
Article Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects
Announcements Drug Design, Development and Therapy Date of publication 202106
Co-researcher Sejung Hwang, Dae Young Lee, Joo-Youn Cho, Jae-Yong Chung, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34103898/
Education / Career
Article Metabolic fingerprinting uncovers the distinction between the phenotypes of tuberculosis-associated COPD and smoking-induced COPD
Announcements Frontiers in Medicine Date of publication 202105
Co-researcher Da Jung Kim, Jee Youn Oh, Chin Kook Rhee, Seoung Ju Park, Jae Jeong Shim, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34055821/
Education / Career
Article Assessment of Oral Vancomycin-Induced Alterations in Gut Bacterial Microbiota and Metabolome of Healthy Men
Announcements Front Cell Infect Microbiol Date of publication 202105
Co-researcher Andrew HyoungJin Kim, Yujin Lee, Eunwoo Kim, Sang Chun Ji, Jae-Yong Chung, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/34123865/
Education / Career
Article Comparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP�) Biosimilar, to Those of NESP� After a Single Subcutaneous or Intravenous Administration to Healthy Subjects
Announcements Drug Des Devel Ther. Date of publication 202104
Co-researcher Inseung Jeon, Jaeseong Oh, Yu-Kyung Kwon, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33953543/
Education / Career
Article A pilot study to investigate the utility of NAT2 genotype-guided isoniazid monotherapy regimens in NAT2 slow acetylators
Announcements Pharmacogenetics and genomics. Date of publication 202104
Co-researcher Hyounggyoon Yoo, Sang Chun Ji , Joo-Youn Cho, Sang-Heon Kim , Jihoon G Yoon, Min Goo Lee, Kyung-Sang Yu , In-Jin Jang, Jaeseong Oh
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33165168/
Education / Career
Article Pharmacokinetics and Safety of Extended-release Ranolazine in Korean and White Healthy Subjects
Announcements Clinical therapeutics. Date of publication 202103
Co-researcher Hyounggyoon Yoo, Sang Won Lee, Deok Yong Yoon, Seo Hyun Yoon, Joo-Youn Cho, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33518355/
Education / Career
Article Metastasis-on-a-chip reveals adipocyte-derived lipids trigger cancer cell migration via HIF-1α activation in cancer cells
Announcements Biomaterials. Date of publication 202102
Co-researcher Jieun Seo, Kyeong Seog Kim, Jong-Wan Park, Joo-Youn Cho, Hak Chang, Junji Fukuda, Ki Yong Hong, Yang-Sook Chun
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33385686/
Education / Career
Article The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis
Announcements Sci Rep Date of publication 202102
Co-researcher Yujin Lee, Eun Lee, Dong Keon Yon, Hye Mi Jee, Hey Sung Baek, Seung Won Lee, Joo-Youn Cho, Man Yong Han
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33580129/
Education / Career
Article Urinary metabolic markers reflect on hepatic, not intestinal, CYP3A activity in healthy subjects
Announcements Drug Metab Pharmacokinet Date of publication 202102
Co-researcher Soyoung Lee, Yujin Lee, Andrew HyoungJin Kim, Sumin Yoon, Jieon Lee, Sang Chun Ji, Seo Hyun Yoon, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33348239/
Education / Career
Article The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects
Announcements Drug Metab Pharmacokinet Date of publication 202102
Co-researcher Soyoung Lee, Andrew HyoungJin Kim, Sumin Yoon, Jieon Lee, Yujin Lee, Sang Chun Ji, Seo Hyun Yoon, SeungHwan Lee, Kyung-Sang Yu , In-Jin Jang , Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33348240/
Education / Career
Article Pharmacokinetics and Pharmacodynamics of Ursodeoxycholic Acid in an Overweight Population With Abnormal Liver Function
Announcements Clinical pharmacology in drug development Date of publication 202101
Co-researcher Seonghae Yoon, Heechan Lee, Sang-Chun Ji , Seo Hyun Yoon, Joo-Youn Cho, Jae-Yong Chung
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32191400/
Education / Career
Article Gut microorganisms and their metabolites modulate the severity of acute colitis in a tryptophan metabolism-dependent manner.
Announcements European journal of nutrition Date of publication 202012
Co-researcher Ji-Hee Shin, Young-Kwan Lee, Woo-Jeong Shon, Bora Kim, Che Ok Jeon, Joo-Youn Cho, Herbert C. Morse III, Eun Young Choi & Dong-Mi Shin
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32055962/
Education / Career
Article Population Pharmacokinetic Analysis of Amikacin for Optimal Pharmacotherapy in Korean Patients with Nontuberculous Mycobacterial Pulmonary Disease
Announcements Antibiotics. Date of publication 202011
Co-researcher Xuanyou Jin, Jaeseong Oh, Joo-Youn Cho, SeungHwan Lee, Su-Jin Rhee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/33172135/
Education / Career
Article Impact of vancomycin-induced changes in the intestinal microbiota on the pharmacokinetics of simvastatin.
Announcements Clin Transl Sci Date of publication 202007
Co-researcher Jung Sunwoo Sang Chun Ji Andrew HyoungJin Kim Kyung‐Sang Yu Joo‐Youn Cho In‐Jin Jang SeungHwan Lee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32058642/
Education / Career
Article Development and validation of a method for the simultaneous quantification of endogenous steroids metabolized by CYP3A
Announcements Transl Clin Pharmacol Date of publication 202006
Co-researcher Yujin Lee, Woori Chae, Seonghae Yoon, Jae-Yong Chung, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32656158/
Education / Career
Article Phase I and pharmacokinetic study of the vascular-disrupting agent CKD-516 (NOV120401) in patients with refractory solid tumors.
Announcements Pharmacology Research & Perspectives Date of publication 202004
Co-researcher Hark Kyun Kim Jeong Won Kang Young‐Whan Park Jung Young Kim Minchae Kim Soo Jin Kim Se‐mi Kim Keun Ho Ryu Seonghae Yoon Yun Kim Joo‐Youn Cho Keun Seok Lee Tak Yun Kiwon Kim Mi Hyang Kwak Tae‐Sung Kim Jinsoo Chung Joong‐Won Park
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32162844/
Education / Career
Article Mechanism of Chronic Kidney Disease Progression and Novel Biomarkers: A Metabolomic Analysis of Experimental Glomerulonephritis
Announcements Metabolites Date of publication 202004
Co-researcher Kyoung Hee Han, Bora Kim, Sang Chun Ji, Hee Gyung Kang, Hae Il Cheong, Joo-Youn Cho, Il-Soo Ha
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32344531/
Education / Career
Article A Comprehensive Proteomic and Phosphoproteomic Analysis of Retinal Pigment Epithelium Reveals Multiple Pathway Alterations in Response to the Inflammatory Stimuli
Announcements International journal of molecular sciences Date of publication 202004
Co-researcher Juha Song, Dohyun Han, Heonyi Lee, Da Jung Kim, Joo-Youn Cho, Jae-Hak Park, Seung Hyeok Seok
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32344885/
Education / Career
Article Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of gemigliptin/metformin Sustained Release 25/500 Mg Compared to the Loose Combination in Healthy Male Subjects
Announcements Translational and clinical pharmacology Date of publication 202003
Co-researcher Xuanyou Jin, Eunwoo Kim, Ki Young Huh, Inyoung Hwang, Joo-Youn Cho, Kyung-Sang Yu, SeungHwan Lee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32274380/
Education / Career
Article Complex influences of gut microbiome metabolism on various drug responses
Announcements Transl Clin Pharmacol Date of publication 202003
Co-researcher Sihyun Chae, Da Jung Kim, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32274377/
Education / Career
Article External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old
Announcements J Korean Med Sci Date of publication 202003
Co-researcher Sang Hwan Ji, Ji Hyun Lee , Joo Youn Cho, Hwa Suk Kim, Young Eun Jang, Eun Hee Kim , Jin Tae Kim, Hee Soo Kim
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32193901/
Education / Career
Article Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer's disease animal model.
Announcements Molecular brain. Date of publication 202002
Co-researcher Hyunju Kim, Bora Kim, Hye-Sun Kim, Joo-Youn Cho,
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32033569/
Education / Career
Article Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles.
Announcements Scientific reports Date of publication 202002
Co-researcher Da Jung Kim, Jinho Yang, Hochan Seo, Won Hee Lee, Dong Ho Lee, Sungmin Kym, Young Soo Park, Jae Gyu Kim, In-Jin Jang, Yoon-Keun Kim, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/32071370/
Education / Career
Article Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects.
Announcements Scientific reports Date of publication 201912
Co-researcher Yun Kim, Seonghae Yoon, Yewon Choi, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, Jae-Yong Chung
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/31857620/
Education / Career
Article Indoxyl sulfate-induced TNF-α is regulated by crosstalk between the aryl hydrocarbon receptor, NF-κB, and SOCS2 in human macrophages.
Announcements FASEB journal Date of publication 201910
Co-researcher Kim HY, Yoo TH, Cho JY, Kim HC, Lee WW
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/31284759/
Education / Career
Article A Population Pharmacokinetic Model of Intravenous Dexmedetomidine for Mechanically Ventilated Children after Neurosurgery.
Announcements Journal of clinical medicine. Date of publication 201910
Co-researcher Song IK, Yi S, Lim HS, Lee JH, Kim EH, Cho JY, Kim MC, Kim JT, Kim HS
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/31581476/
Education / Career
Article Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis
Announcements Cancers Date of publication 201910
Co-researcher Kim DJ, Cho EJ, Yu KS, Jang IJ, Yoon JH, Park T, Cho JY
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/31590436/
Education / Career
Article Pharmacokinetics of Ursodeoxycholic Acid in Elderly Volunteers Compared With Younger Adults in a Korean Population.
Announcements Journal of clinical pharmacology Date of publication 201908
Co-researcher Lee S, Yoon S, Chung H, Ji SC, Yoon SH, Yu KS, Cho JY, Chung JY
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30882914/
Education / Career
Article Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers.
Announcements Drug metabolism and pharmacokinetics Date of publication 201908
Co-researcher Jieon Lee, Seo Hyun Yoon, Sojeong Yi, Andrew HyoungJin Kim, Bora Kim,SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/31088714/
Education / Career
Article Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry.
Announcements Journal of Korean medical science (JKMS) Date of publication 201904
Co-researcher Kim JS, Kim AH, Jang C, Jang IJ, Kim KB, Cho JY, Hwang HY
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30950250/
Education / Career
Article Ursodeoxycholic acid exerts hepatoprotective effects by regulating amino acid, flavonoid, and fatty acid metabolic pathways
Announcements Metabolomics Society Date of publication 201902
Co-researcher Da Jung Kim , Hyewon Chung, Sang Chun Ji, SeungHwan Lee,Kyung‑Sang Yu, In‑Jin Jang, Joo‑Youn Cho
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30830474/
Education / Career
Article A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers
Announcements EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Date of publication 201812
Co-researcher 이소영,윤승혜,조주연,정재용,김윤,임광진,이지성
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30136102/
Education / Career
Article Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity.
Announcements Genomics & Informatics Date of publication 201811
Co-researcher 장인진,조주연,유경상,오재성,이소정,구남이,신동성,윤서현
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30309203/
Education / Career
Article Phloroglucinol ameliorates cognitive impairments by reducing the amyloid beta peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice
Announcements FREE RADICAL BIOLOGY AND MEDICINE Date of publication 201810
Co-researcher 양은정,우스만 마흐무드,김혜선,장문정,김현주,최문석,최윤정,이진표,조주연,현진원,김용식
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30118828/
Education / Career
Article Effect of food on the pharmacokinetics of YH4808, a potassium-competitive acid blocker, after single- and multiple-oral dosing in healthy subjects
Announcements EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Date of publication 201810
Co-researcher 조주연,Kim, E , Kim, A , Yi, S , Kim, YK , Jang, SB , Byun, HM , Yoon, SH ,장인진,유경상, Lee, S
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29907887/
Education / Career
Article Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics
Announcements CHEMISTRY AND PHYSICS OF LIPIDS Date of publication 201808
Co-researcher 조주연,Lee, H , Choi, JM , Kim, TE , Lee, HJ , Jung, BH
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29852124/
Education / Career
Article The Genetic Polymorphism UGT1A4*3 Is Associated with Low Posaconazole Plasma Concentrations in Hematological Malignancy Patients Receiving the Oral Suspension
Announcements ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Date of publication 201807
Co-researcher 서현정,윤서현,박완범,김남중,김홍빈,김인호,오명돈,유경상,조주연,Sang-In Park,Eunyoung Lee,Jeong-Ok Lee,Youngil Koh,Kyoung-Ho Song,Pyoeng Gyun Choe,Eu Suk Kim,Soo-Mee Bang,Sang Hoon Song
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29661871/
Education / Career
Article Assessment of induced CYP3A activity in pregnant women using 4 beta-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker
Announcements DRUG METABOLISM AND PHARMACOKINETICS Date of publication 201806
Co-researcher Andrew HyoungJinKim,BoraKim,조주연,박중신,유경상,장인진,Su-jinRhee,YujinLee,Seung MiLee,Sun MinKim,SeungHwanLee
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29759884/
Education / Career
Article A phase 4 study of nilotinib in Korean patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTKorea
Announcements CANCER MEDICINE Date of publication 201805
Co-researcher Shin, J ,김인호, Koh, Y , Yoon, SH ,조주연, Kim, DY , Lee, KH , Kim, HJ , Ahn, JS , Kim, YK , Park, J , Sohn, SK , Moon, JH , Lee, YJ , Yoon, S , Lee, JO , Cheong, JW , Ha Kim, K , Kim, SH , Kim, HG , Kim, H , Nam, SH , Do, YR , Park, SG , Park, SK , Bae, SH , Song, HH , Shin, DY , Oh, D , Kim, MK , Jung, CW , Park, S
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29577674/
Education / Career
Article Identification of - or (-1)-Hydroxylated Medium-Chain Acylcarnitines as Novel Urinary Biomarkers for CYP3A Activity
Announcements CLINICAL PHARMACOLOGY & THERAPEUTICS Date of publication 201805
Co-researcher 김보라,조주연,이지언,신광희,이승환,유경상,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28877336/
Education / Career
Article Early Therapeutic Drug Monitoring of Posaconazole Oral Suspension in Patients With Hematologic Malignancies
Announcements THERAPEUTIC DRUG MONITORING Date of publication 201802
Co-researcher Suh, HJ ,김인호, Song, SH , Park, WB ,김남중,조주연, Park, SI , Yoon, SH , Hwang, JH , Bae, JY , Lee, JO , Koh, Y , Song, KH , Choe, PG ,유경상, Kim, ES ,김홍빈, Bang, SM ,오명돈
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29189664/
Education / Career
Article Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet
Announcements DRUG DESIGN DEVELOPMENT AND THERAPY Date of publication 201801
Co-researcher 조주연,Lee, S , Nam, KY , Oh, J , Lee, S , Cho, SM , Choi, YW , Lee, BJ , Hong, JH
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29872264/
Education / Career
Article A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study
Announcements PLOS ONE Date of publication 201801
Co-researcher Chung, H ,정재용,유경상, Oh, J , Yoon, SH ,조주연
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29342199/
Education / Career
Article Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment
Announcements JOURNAL OF KOREAN MEDICAL SCIENCE Date of publication 201801
Co-researcher Kim, AH , Yoon, S ,조주연, Lee, Y , Lee, J , Bae, E , Lee, H ,김동기, Lee, S ,유경상,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30595680/
Education / Career
Article Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction
Announcements SCIENTIFIC REPORTS Date of publication 201801
Co-researcher 조주연,Kim, DJ , Yoon, S , Ji, SC , Yang, J , Kim, YK , Lee, S ,유경상,장인진,정재용
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/30089798/
Education / Career
Article Active maintenance of endothelial cells prevents kidney fibrosis
Announcements Kidney Research and Clinical Practice Date of publication 201712
Co-researcher 양승희,김용철,이정표,오윤규,안정남,김진혁,이주호,이희윤,백진호,임춘수,김연수,조주연
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29285425/
Education / Career
Article Risk factors for suboptimal drug concentration of posaconazole oral suspension in patients with hematologic malignancy
Announcements JOURNAL DE MYCOLOGIE MEDICALE Date of publication 201712
Co-researcher Kim, EJ ,유경상,김인호, Na, SH , Nam, EY , Oh, HS , Kim, M , Yoon, SH , Lee, JO , Koh, Y , Song, KH , Choe, PG ,조주연, Song, SH , Kim, ES ,김홍빈, Bang, SM ,김남중, Oh, MD , Park, WB
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28867258/
Education / Career
Article Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials
Announcements DRUG DESIGN DEVELOPMENT AND THERAPY Date of publication 201711
Co-researcher 조주연,Kim, S , Lee, S , Yoon, SH ,장인진,유경상
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29158665/
Education / Career
Article Performance of the Minto model for the target-controlled infusion of remifentanil during cardiopulmonary bypass
Announcements ANAESTHESIA Date of publication 201710
Co-researcher Cho, YJ , Kim, TK ,유경상, Jo, WY , Oh, H , Koo, C-H , Oh, J ,조주연,전윤석
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28891056/
Education / Career
Article An Accelerator Mass Spectrometry-Enabled Microtracer Study to Evaluate the First-Pass Effect on the Absorption of YH4808
Announcements CLINICAL PHARMACOLOGY & THERAPEUTICS Date of publication 201709
Co-researcher 조주연,Kim, A , Yu, BY , Dueker, SR , Shin, KH , Kim, HS , Ahn, H ,유경상,장인진, Lee, H
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28214288/
Education / Career
Article The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein
Announcements BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Date of publication 201709
Co-researcher Kim, TE ,조주연,유경상, Shin, D , Gu, N , Jung, BH , Kim, J ,조영민
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28627804/
Education / Career
Article Urinary Metabolomic Signatures in Obstructive Sleep Apnea through Targeted Metabolomic Analysis: A Pilot Study
Announcements METABOLOMICS Date of publication 201708
Co-researcher Cho, K , Yoon, DW ,조주연,신현우,박종완, Lee, M , So, D , Hong, IH ,이재서
Education / Career
Article LBEC0101, A Proposed Etanercept Biosimilar: Pharmacokinetics, Immunogenicity, and Tolerability Profiles Compared with a Reference Biologic Product in Healthy Male Subjects
Announcements BIODRUGS Date of publication 201708
Co-researcher Lee, H ,유경상, Chung, H , Lee, S , Lee, H , Yang, SM , Yoon, SH ,조주연,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28551775/
Education / Career
Article A novel K plus competitive acid blocker, YH4808, sustains inhibition of gastric acid secretion with a faster onset than esomeprazole: randomised clinical study in healthy volunteers
Announcements ALIMENTARY PHARMACOLOGY & THERAPEUTICS Date of publication 201708
Co-researcher Yi, S ,유경상, Lee, H , Jang, SB , Byun, HM , Yoon, SH ,조주연,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28543183/
Education / Career
Article Plasma LTE4/PGF(2 alpha) Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation
Announcements ALLERGY ASTHMA & IMMUNOLOGY RESEARCH Date of publication 201707
Co-researcher 조주연,Ban, GY , Ye, YM , Kim, SH , Hur, GY , Kim, JH , Shim, JJ , Cho, K , Park, HS
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28497926/
Education / Career
Article Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females
Announcements AAPS JOURNAL Date of publication 201707
Co-researcher Lee, J ,조주연,유경상, Kim, AH , Yi, S , Lee, S , Yoon, SH ,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28523515/
Education / Career
Article Integrative Analysis of Renal Ischemia/Reperfusion Injury and Remote Ischemic Preconditioning in Mice
Announcements JOURNAL OF PROTEOME RESEARCH Date of publication 201707
Co-researcher 조금선,민상일,조주연,하종원,민승기,안상현,안규리,유경상,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28627174/
Education / Career
Article Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea
Announcements GUT AND LIVER Date of publication 201707
Co-researcher Choi, YJ ,김나영,장인진,조주연, Nam, RH , Park, JH , Jo, HJ , Yoon, H , Shin, CM , Park, YS ,이동호,정현채
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28395507/
Education / Career
Article High-Fat Diet and Voluntary Chronic Aerobic Exercise Recover Altered Levels of Aging-Related Tryptophan Metabolites along the Kynurenine Pathway
Announcements Experimental Neurobiology Date of publication 201706
Co-researcher 조주연,이건주,정근화,이순태,Hwa Suk Kim,Jun Hwa Shim,이상건,김만호,Kon Chu
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28680298/
Education / Career
Article Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers
Announcements ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Date of publication 201706
Co-researcher Jun, SY , Kang, SH ,성문우,장인진, Yoon, S , Jang, K ,유경상,조주연, Jung, GM , Yoon, SJ
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28348152/
Education / Career
Article Comparison of plasma concentrations of posaconazole with the oral suspension and tablet in Korean patients with hematologic malignancies
Announcements Infection and Chemotherapy Date of publication 201706
Co-researcher 서현정,김인호,박완범,김남중,조주연,박상인,윤서현,이정옥,고영일,송경호,최평균,유경상,김의석,김홍빈,방수미,송상훈,오명돈
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28608665/
Education / Career
Article Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants
Announcements BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Date of publication 201706
Co-researcher 손지나,김한석,조주연,유경상,오재성,이주영,신승한,이지나,최창원,김이경,김병일,박은애
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27995649/
Education / Career
Article Pharmacokinetic comparison using two tablets of an evogliptin/metformin XR 2.5/500 mg fixed dose combination vs. 1 tablet each of evogliptin 5 mg and metformin XR 1,000 mg
Announcements INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Date of publication 201706
Co-researcher Yoon, S ,유경상, Rhee, SJ , Park, SI , Yoon, SH ,조주연,장인진, Lee, S
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28406090/
Education / Career
Article Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches
Announcements CTS-CLINICAL AND TRANSLATIONAL SCIENCE Date of publication 201705
Co-researcher Lee J,Ji SC,장인진,Kim SH,유경상,조주연,정재용,Park HS,Yoon SH,Lee SH,Kim B,Yi S,Shin KH,Lim KS
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27785887/
Education / Career
Article A randomized, double-blind, single-dose, two-arm, parallel study comparing pharmacokinetics, immunogenicity and tolerability of branded adalimumab and its biosimilar LBAL in healthy male volunteers
Announcements EXPERT OPINION ON INVESTIGATIONAL DRUGS Date of publication 201705
Co-researcher Park, KR ,유경상, Chung, H , Yang, SM , Lee, S , Yoon, SH ,조주연,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28290731/
Education / Career
Article Combined untargeted and targeted metabolomic profiling reveals urinary biomarkers for discriminating obese from normal-weight adolescents
Announcements PEDIATRIC OBESITY Date of publication 201704
Co-researcher Cho, K ,조주연, Moon, JS ,유경상, Kang, JH , Jang, HB , Lee, HJ , Park, SI
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/26910390/
Education / Career
Article Randomised clinical trial: the efficacy and safety of oltipraz, a liver X receptor alpha-inhibitory dithiolethione in patients with non-alcoholic fatty liver disease
Announcements ALIMENTARY PHARMACOLOGY & THERAPEUTICS Date of publication 201704
Co-researcher 김원,김병관,김윤준,이준성,이천균,연종은,장미수,김정호,김현진,이소정,이종태,조주연,김상건,이정훈
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28225186/
Education / Career
Article Targeted Next-Generation Sequencing for Comprehensive Genetic Profiling of Pharmacogenes
Announcements CLINICAL PHARMACOLOGY & THERAPEUTICS Date of publication 201703
Co-researcher Han SM,Lee MG,장인진,Park J,Lee JH,조주연,Lee SS,Kim H,Han H,Kim Y,Yi S
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27727443/
Education / Career
Article Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel dipeptidyl peptidase-4 inhibitor, evogliptin (DA-1229)
Announcements DIABETES OBESITY & METABOLISM Date of publication 201702
Co-researcher Oh, J ,유경상, Kim, AH , Lee, S , Cho, H , Kim, YS , Bahng, MY , Yoon, SH ,조주연,장인진
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27761990/
Education / Career
Article The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans
Announcements PLOS ONE Date of publication 201701
Co-researcher Oh, J ,유경상, Lee, S , Lee, H ,조주연, Yoon, SH ,장인진, Lim, KS
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28437488/
Education / Career
Article Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients
Announcements SCIENTIFIC REPORTS Date of publication 201701
Co-researcher Kim, B , Lee, JW ,강형진,조주연, Hong, KT ,유경상,장인진, Park, KD ,신희영, Ahn, HS
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28490733/
Education / Career
Article Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD)
Announcements SCIENTIFIC REPORTS Date of publication 201701
Co-researcher Kim, HY ,이원우, Yoo, TH , Hwang, Y , Lee, GH , Kim, B , Jang, J , Yu, HT , Kim, MC ,조주연, Lee, CJ , Kim, HC , Park, S
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28596556/
Education / Career
Article Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon (R) and Eprex (R) following a single subcutaneous administration in healthy male volunteers
Announcements DRUG DESIGN DEVELOPMENT AND THERAPY Date of publication 201701
Co-researcher Yoon, S ,유경상, Rhee, SJ , Heo, SJ , Oh, TY , Yoon, SH ,조주연, Lee, S
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/29138535/
Education / Career
Article Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects
Announcements DRUG DESIGN DEVELOPMENT AND THERAPY Date of publication 201701
Co-researcher Shin, D ,조주연, Lee, S , Yi, S , Yoon, SH , Bahng, MY ,장인진,유경상
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28331291/
Education / Career
Article Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease
Announcements CLINICAL AND EXPERIMENTAL ALLERGY Date of publication 201701
Co-researcher 조주연,Ban, GY , Cho, K , Kim, SH , Yoon, MK , Kim, JH , Lee, HY , Shin, YS , Ye, YM , Park, HS
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27533637/
Education / Career
Article Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers
Announcements DRUG DESIGN DEVELOPMENT AND THERAPY Date of publication 201701
Co-researcher Jang, K , Kim, MK , Lim, KS ,유경상, Oh, J , Lee, S ,조주연, Choi, TK , Lee, SH
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28331290/
Education / Career
Article A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers
Announcements DRUG DESIGN DEVELOPMENT AND THERAPY Date of publication 201701
Co-researcher Lee, J , Lee, S , Gu, N ,유경상, Kim, BH , Kim, HS , Kim, JD ,조주연
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/28479852/
Education / Career
Article Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults
Announcements INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Date of publication 201701
Co-researcher 정혜원,정재용,조주연,김언혜,유경상,윤서현,임경수,박상인
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27741028/
Education / Career
Article Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease
Announcements SCIENTIFIC REPORTS Date of publication 201611
Co-researcher Trinh, HKT , Kim, SC , Park, HS , Kim, SH ,조주연, Cho, K , Kim, SJ , Ban, GY , Yoo, HJ
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27830727/
Education / Career
Article GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism
Announcements JOURNAL OF IMMUNOLOGY Date of publication 201611
Co-researcher Na, YR , Gu, GJ ,석승혁,조주연, Jung, D , Kim, YW , Na, J , Woo, JS , Youn, H
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27742831/
Education / Career
Article Urinary 6 beta-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach
Announcements AAPS JOURNAL Date of publication 201609
Co-researcher 신광희,안리영,조주연,유경상,장인진,최만호,문주연,이지언
Pubmed URL https://www.ncbi.nlm.nih.gov/pubmed/27317471/

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